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AI & Data Science Preprint PDF DOI

MIMIC: A Generative Multimodal Foundation Model for Biomolecules

Siavash Golkar, Jake Kovalic, Irina Espejo Morales, Samuel Sledzieski, Minhuan Li, Ksenia Sokolova, Geraud Krawezik, Alberto Bietti, Claudia Skok Gibbs, Roman Klypa, Shengwei Xiong, Francois Lanusse, Liam Parker, Kyunghyun Cho, Miles Cranmer, Tom Hehir, Michael McCabe, Lucas Meyer, Rudy Morel, Payel Mukhopadhyay, Mariel Pettee, Helen Qu, Jeff Shen, David Fouhey, Hadi Sotoudeh, Vikram Mulligan, Pilar Cossio, Sonya M. Hanson, Alisha N. Jones, Olga G. Troyanskaya, Shirley Ho · 2026

Biological function emerges from coupled constraints across sequence, structure, regulation, evolution, and cellular context, yet most foundation models in biology are trained within one modality or f…

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Physics Preprint PDF DOI

Single-Shot Lensless Imaging with Physics Guided Genetic Programming

Ganesh M. Balasubramaniam, Xiao-Liu Chu, Radhika V. Nair, Matthew R. Foreman · 2026

Lensless optical imaging eliminates the need for refractive optics, enabling compact and low-cost cameras with a large field-of-view, supporting point-of-care diagnostics and industrial monitoring. Pr…

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AI & Data Science Preprint PDF DOI

Ranking Abuse via Strategic Pairwise Data Perturbations

Junyi Yao, Zihao Zheng, Jiayu Long · 2026

Pairwise ranking systems based on Maximum Likelihood Estimation (MLE), such as the Bradley-Terry model, are widely used to aggregate preferences from pairwise comparisons. However, their robustness un…

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AI & Data Science Preprint PDF DOI

A Systematic Survey and Benchmark of Deep Learning for Molecular Property Prediction in the Foundation Model Era

Zongru Li, Xingsheng Chen, Honggang Wen, Regina Qianru Zhang, Ming Li, Xiaojin Zhang, Hongzhi Yin, Qiang Yang, Kwok-Yan Lam, Pietro Lio, Siu-Ming Yiu · 2026

Molecular property prediction integrates quantum chemistry, cheminformatics, and deep learning to connect molecular structure with physicochemical and biological behavior. This survey traces four comp…

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Computer Science Preprint PDF DOI

Low-Stack HAETAE for Memory-Constrained Microcontrollers

Gustavo Banegas (LIX, GRACE), Kim Youngbeom, Seo Seog Chung, Vredendaal Christine Van · 2026

We present a low-stack implementation of the module-lattice signature scheme HAETAE, targeting microcontrollers with 8 kB-16 kB of available SRAM. On such devices, peak stack usage is often the bindin…

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AI & Data Science Preprint PDF DOI

The Metacognitive Monitoring Battery: A Cross-Domain Benchmark for LLM Self-Monitoring

Jon-Paul Cacioli · 2026

We introduce a cross-domain behavioural assay of monitoring-control coupling in LLMs, grounded in the Nelson and Narens (1990) metacognitive framework and applying human psychometric methodology to LL…

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Biology & Life Sciences Preprint PDF DOI

Drug-delivery Ca-Mg silicate scaffolds encapsulated in PLGA

A. Jadidi, E. Salahinejad, E. Sharifi, L. Tayebi · 2026

The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca7MgSi4O16) porous scaf…

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Biology & Life Sciences Preprint PDF DOI

Competition of carrier bioresorption and drug release kinetics of vancomycin-loaded silicate macroporous microspheres to determine cell biocompatibility

A. Bolandparvaz Jahromi, E. Salahinejad · 2026

Bioceramic porous microspheres are promising substances for dental and orthopedic bone void filling, tissue engineering and drug delivery applications. In this research, the structure and cytocompatib…

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AI & Data Science Preprint PDF DOI

A Generative Foundation Model for Multimodal Histopathology

Jinxi Xiang, Mingjie Li, Siyu Hou, Yijiang Chen, Xiangde Luo, Yuanfeng Ji, Xiang Zhou, Ehsan Adeli, Akshay Chaudhari, Curtis P. Langlotz, Kilian M. Pohl, Ruijiang Li · 2026

Accurate diagnosis and treatment of complex diseases require integrating histological, molecular, and clinical data, yet in practice these modalities are often incomplete owing to tissue scarcity, ass…

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Physics Preprint PDF DOI

Organic Electrochemical Transistor Arrays with Integrated Lipid-Sealed Femtolitre Chambers for Simultaneous Electrical and Optical Detection of Membrane Protein Activity

S. Kojima, S. Rawat, M. Sanchez Miranda, J.G. Gluschke, H. Noji, L.K. Lee, A.P. Micolich · 2026

We report a method for producing an array of fifty two ion-sensitive PEDOT:PSS organic electrochemical transistors on a glass coverslip, each featuring an integrated fluoropolymer microwell sealed wit…

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Biology & Life Sciences Preprint PDF DOI

Stiff-FCS: Single-Cell Stiffness Profiling With Integrated Molecular and Functional Analysis

Yuhao Zhang, Luyao Zhao, Zhengfu Huang, Kenan Song, Xianqiao Wang, Xianyan Chen, Jin Xie, Yiping Zhao, He Li, Leidong Mao, Yong Teng, Yang Liu · 2026

Cell stiffness is a key determinant of how cells deform, migrate, and adapt to mechanically restrictive environments, yet existing single-cell stiffness assays remain difficult to combine with molecul…

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AI & Data Science Preprint PDF DOI

When Bayes goes bad: Weakly-regularized covariate adjustment leads to a biased estimate of prevalence

Swen Kuh, Lauren Kennedy, Qixuan Chen, Andrew Gelman · 2026

When estimating population prevalence from a non-random sample, it is important to adjust for differences between sample and population. However, adjustment for multiple factors requires analysis that…

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AI & Data Science Preprint PDF DOI

RINO: Rotation-Invariant Non-Rigid Correspondences

Maolin Gao, Shao Jie Hu-Chen, Congyue Deng, Riccardo Marin, Leonidas Guibas, Daniel Cremers · 2026

Dense 3D shape correspondence remains a central challenge in computer vision and graphics as many deep learning approaches still rely on intermediate geometric features or handcrafted descriptors, lim…

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Engineering Preprint PDF DOI

Quantitative measurements of biological/chemical concentrations using smartphone cameras

Zhendong Cao, Hongji Dai, Zhida Li, Ash Parameswaran · 2026

This paper presents a smartphone-based imaging system capable of quantifying the concentration of an assortment of biological/chemical assay samples. The main objective is to construct an image databa…

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AI & Data Science Preprint PDF DOI

Conchordal: Emergent Harmony via Direct Cognitive Coupling in a Psychoacoustic Landscape

Koichi Takahashi · 2026

This paper introduces Conchordal, a bio-acoustic instrument for generative composition whose sonic agents are governed by artificial life dynamics within a psychoacoustic fitness landscape. The system…

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Mathematics Preprint PDF DOI

Asymptotically geodesic hypersurfaces and the fundamental groups of hyperbolic manifolds

Xiaolong Hans Han, Ruojing Jiang · 2026

We consider closed hypersurfaces smoothly immersed in hyperbolic manifolds up to homotopy and commensurability. We prove that if a closed hyperbolic manifold $M$ contains a sequence of asymptotically …

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Biology & Life Sciences Preprint PDF DOI

Interfacial Potential Transduction for Diagnostics

Hyun-June Jang, Peuli Nath, Yuqin Wang, Mingoo Kim, Rohit Sai Kodam, Soobin Han, Sangmin Lee, Wookjin Na, Jihoon Kim, Xiaoao Shi, Jeff J. H. Kim, HyunKeun Joo, Byunghoon Ryu, Kiang-Teck Jerry Yeo, Seung-Jung Kee, Howard E. Katz, Junhong Chen, Youngung Seok, Yun Suk Huh, Dino Di Carlo, Hyou-Arm Joung · 2026

A major barrier to decentralized, near-patient diagnostics is the lack of a signal transduction modality that is both analytically precise and accessible at the point of care. Optical readouts remain …

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Biology & Life Sciences Preprint PDF DOI

Tracking Carbapenem-Resistant Pathogens in Hospital Wastewater: the focus on Acinetobacter baumannii and Pseudomonas aeruginosa

Magdalena Mecik, Kornelia Stefaniak, Monika Harnisz, Ewa Felis, Sylwia Bajkacz, Joanna Wilk, Karolina Dudek, Ewa Korzeniewska · 2026

Carbapenem-resistant Pseudomonas aeruginosa (CRPA) and Acinetobacter baumannii (CRAB) represent a major clinical and epidemiological challenge and pose a growing threat to public health and the enviro…

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AI & Data Science Preprint PDF DOI

Estimands and the Choice of Non-Inferiority Margin under ICH E9(R1)

Tobias Mutze, Helle Lynggaard, Sunita Rehal, Oliver N. Keene, Marian Mitroiu, David Wright · 2026

Since the release of the ICH E9(R1) addendum on estimands, its application in non-inferiority trials has received far less attention than in superiority settings. A key conclusion from Lynggaard et al…

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Computer Science Preprint PDF DOI

Enhancing OLAP Resilience at LinkedIn

Praveen Chaganlal, Jia Guo, Vivek Vaidyanathan, Dino Occhialini, Sonam Mandal, Subbu Subramaniam, Siddharth Teotia, Tianqi Li, Xiaxuan Gao, Florence Zhang · 2026

Real-time OLAP datastores are critical infrastructure for modern enterprises, powering interactive analytics on petabyte-scale datasets with subsecond latency requirements. As these systems become int…

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