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Physics Preprint PDF DOI

Propelling catalytic structures using active phase separation

Benjamin Sorkin, Ned S. Wingreen · 2026

Living systems routinely consume energy to achieve motility, often using intricate biomolecular machinery. In this work, we show that active droplets can sustain indefinite self-propulsion of a spheri…

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AI & Data Science Preprint PDF DOI

A Collective Variational Principle Unifying Bayesian Inference, Game Theory, and Thermodynamics

Djamel Bouchaffra, Faycal Ykhlef, Mustapha Lebbah, Hanane Azzag · 2026

Collective intelligence emerges across biological, physical, and artificial systems without central coordination, yet a unifying principle governing such behaviour remains elusive. The Free Energy Pri…

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Biology & Life Sciences Preprint PDF DOI

Neural Investment as an Entropy-Budget Strategy: A Thermodynamic Derivation of Primate Longevity from the Principle of Biological Time Equivalence

Mesfin Taye · 2026

Primates exhibit a robust deviation from canonical allometric scaling: at fixed body mass, their lifespans exceed those of non-primate mammals by factors of two to three. A rhesus macaque (8 kg) lives…

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Computer Science Preprint PDF DOI

Synthetic Biological Intelligence: System-Level Abstractions and Adaptive Bio-Digital Interaction

Martin Schottlender, Pengjie Zhou, Veronika Volkova, Fatima Rani, Ruifeng Zheng, Juan A. Cabrera, Frank H.P. Fitzek, Pit Hofmann · 2026

Concurrent advances across fields such as organoid technology, Microelectrode Arrays (MEAs), neuromorphic computing, and machine learning have given rise to a groundbreaking research paradigm: Synthet…

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Sociology & Anthropology Preprint PDF DOI

Scale-freeness under node removal: a finite-size scaling perspective

Yeonsu Jeong, Deok-Sun Lee, Mi Jin Lee, Seung-Woo Son · 2026

In heterogeneous network systems such as ecological and social networks, structural stability depends on how connectivity changes under node removal, as different removal sequences can trigger distinc…

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AI & Data Science Preprint PDF DOI

Parameter-Efficient Architectural Modifications for Translation-Invariant CNNs

Nuria Alabau-Bosque, Jorge Vila-Tomas, Paula Dauden-Oliver, Valero Laparra, Jesus Malo · 2026

Convolutional Neural Networks (CNNs) are widely assumed to be translation-invariant, yet standard architectures exhibit a startling fragility: even a single-pixel shift can drastically degrade perform…

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AI & Data Science Preprint PDF DOI

Optimal allocation of trials to sub-regions in crop variety testing with multiple years and correlated genotype effects

Maryna Prus, Lenka Filova, Hans-Peter Piepho, Waqas Ahmed Malik · 2026

Plant breeding and variety trials are usually conducted in multiple environments sampled from a defined target population of environments in order to characterize the performance of breeding lines or …

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Physics Preprint PDF DOI

YOSO: single-frame Gerchberg-Saxton phase retrieval with AI-based data augmentation for in-line holography

Julianna Winnik, Adam Walocha, Wojciech Ogonowski, Wiktor Forjasz, Piotr Arcab, Miko{l}aj Rogalski, Aleksandra Rutkowska, Marzena Stefaniuk, Jose Angel Picazo-Bueno, Vicente Mico, Maciej Trusiak, Maria Cywinska · 2026

We present YOSO (You Only Shot Once), a single-frame phase retrieval framework for digital in-line holographic microscopy (DIHM) in which supervised deep learning is used to numerically generate an ad…

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Physics Preprint PDF DOI

Multi-wavelength polarisation imaging with inverse designed metasurfaces

Sarah E. Dean, Neuton Li, Josephine Munro, Benjamin Laudert, Thomas Siefke, Quyet Ngo, Robert Sharp, Dragomir N. Neshev, Falk Eilenberger, Andrey A. Sukhorukov · 2026

Multispectral polarisation imaging has a broad range of applications, from biological cell imaging to agricultural remote surveying. For such applications, especially involving lightweight unmanned ae…

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AI & Data Science Preprint PDF DOI

Contextual Agentic Memory is a Memo, Not True Memory

Binyan Xu, Xilin Dai, Kehuan Zhang · 2026

Current agentic memory systems (vector stores, retrieval-augmented generation, scratchpads, and context-window management) do not implement memory: they implement lookup. We argue that treating lookup…

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Medicine & Health Preprint PDF DOI

Mechanistic driven TCP and NTCP modeling for particle therapy accounting for a broad range of physical irradiation parameters and tissue environmental conditions

Marco Battestini, Jules Morand, Giulio Bordieri, Marta Missiaggia, Emanuele Scifoni, Francesco G. Cordoni · 2026

In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a side effect after the i…

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Physics Preprint PDF DOI

Neuronal arithmetic operators based on Ovonic threshold switches (OTS) for biologically inspired analog computing

Jingyeong Hwang, Jaesang Lee, Jiin Bang, Younghyun Lee, Unhyeon Kang, Seungmin Oh, Kyungmin Lee, Jaehyun Park, Seongsik Park, Hyun Jae Jang, Sangbum Kim, Min Hyuk Park, Suyoun Lee · 2026

Biological neurons perform arithmetic computations - including additive integration and divisive gain modulation - through synaptic conductance changes and shunting inhibition, enabling context-depend…

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Biology & Life Sciences Preprint PDF DOI

Benchmarking virtual cell models for in-the-wild perturbation response

Xinjie Mao, Songming Zhang, Qianhong Wen, Xiangyu Wen, Kedu Jin, Hao Wu, Shuizhou Chen, Yuqiang Li, Lei Bai, Qi Liu, Ning Ding, Siqi Sun, Zhangyang Gao · 2026

Virtual cell (VC) models aim to predict cellular responses to any perturbations in silico and have emerged as a promising approach for drug discovery and precision medicine. Yet, a clear gap still rem…

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Biology & Life Sciences Preprint PDF DOI

A stochastic agent-based extension of the GSM2 model for particle therapy: cell-cycle dynamics, dose-rate dependence, and fractionation effects

Francesco G. Cordoni, Marco Battestini, Marta Missiaggia · 2026

Accurately linking microscopic energy deposition from ionizing radiation to emergent biological outcomes remains a central challenge in radiobiological modelling, particularly when stochastic damage i…

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Computer Science Preprint PDF DOI

BAss: Symbolic Reasoning in Abstract Dialectical Frameworks

Samuel Pastva, Van-Giang Trinh · 2026

We present BAss (BDD-based ADF symbolic solver), a novel analysis tool for Abstract Dialectical Frameworks (ADFs) based on Binary Decision Diagrams (BDDs). It supports the fully symbolic computation o…

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Physics Preprint PDF DOI

Computation of frequency- and time-domain Jacobians in optical tomography with Monte Carlo simulations

Pauliina Hirvi, Jaakko Olkkonen, Qianqian Fang, Ilkka Nissila · 2026

Significance: Jacobians, or spatially resolved sensitivity profiles, are central to image reconstruction in model-based optical tomography of biological tissue. Although Monte Carlo (MC) simulations a…

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Biology & Life Sciences Preprint PDF DOI

Incorporating the underuse problem in the tragedy of the commons

Shota Shibasaki, Wakaba Tateishi, Shuhei Fujii, Ryosuke Nakadai · 2026

The tragedy of the commons has traditionally been framed as a problem of resource overuse driven by self-interested exploitation. In contrast, growing empirical evidence shows that insufficient use or…

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Engineering Preprint PDF DOI

Modeling of Wastewater Treatment Processes with HydroSludge

S. Iserte, P. Carratala, R. Arnau, R. Martinez-Cuenca, P. Barreda, L. Basiero, J. Climent, S. Chiva · 2026

The pressure for Water Resource Recovery Facilities (WRRF) operators to efficiently treat wastewater is greater than ever because of the water crisis, produced by the climate change effects and more r…

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Mathematics Preprint PDF DOI

Boundedness of solutions in feedback systems with antithetic controllers

Moh Kamalul Wafi, Arthur C. B. de Oliveira, Eduardo D. Sontag · 2026

This paper studies whether solutions of a class of nonlinear feedback systems remain bounded over time. The systems we consider arise naturally in synthetic biology, where the antithetic feedback cont…

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Physics Preprint PDF DOI

Confinement-Connectivity Coupling Enables High-Efficiency Piezoionic Transduction

Tofayel Ahammad Ovee, Daniel Kroeger, Jean-Francois Louf · 2026

Piezoionic hydrogels offer a route to mechanically driven bioelectronic interfaces, but their output is limited by rapid, symmetric ion redistribution that dissipates charge gradients. In biological e…

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