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AI & Data Science Preprint PDF DOI

A New Semisupervised Technique for Polarity Analysis using Masked Language Models

Kohei Watanabe ยท 2026

I developed a new version of Latent Semantic Scaling (LSS) employing word2vec as a masked language model. Unlike original spatial models, it assigns polarity scores to words and documents as predictedโ€ฆ

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AI & Data Science Preprint PDF DOI

Dealing with positivity violations in mediation analysis via weighted controlled effects, with application to assessing immune correlates of protection in antigen-experienced participants

Qijia He, Bo Zhang ยท 2026

Causal mediation analysis has become an important and increasingly used framework for evaluating candidate immune response biomarkers in vaccine research. A controlled effects approach has been proposโ€ฆ

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Biology & Life Sciences Preprint PDF DOI

ViraHinter: a dual-modal artificial intelligence framework for predicting virus-host interactions

Weiqiang Bai, Fei Wang, Jialin Wang, Sheng Xu, Lifeng Qiao, Juan Li, Zhuyi Guo, Xiangyun Hou, Lei Bai, Bowen Zhou, Edward C. Holmes, Weifeng Shi, Siqi Sun ยท 2026

Protein-protein interactions (PPIs) between a virus and its host govern infection, replication, and pathogenesis. While high-throughput mapping has identified thousands of virus-host associations, mucโ€ฆ

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AI & Data Science Preprint PDF DOI

Retrospective Economic Evaluation of Group Testing in the COVID-19 Pandemic

Michael Balzer, Kainat Khowaja, Christiane Fuchs ยท 2026

Surveillance of diseases in a pandemic is an important part of public health policy. Diagnostic testing at the individual level is often infeasible due to resource constraints. To circumvent these conโ€ฆ

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Economics & Finance Preprint PDF DOI

Has the COVID-19 Pandemic Altered the Traditional View about Women's Active Work?

Eiji Yamamura, Fumio Ohtake ยท 2026

This study investigates how the view about women's active work changed after the outbreak of the novel coronavirus 2019 (COVID-19) disease. We use individual-level panel data from 2016 to 2024 that coโ€ฆ

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AI & Data Science Preprint PDF DOI

Recovery-Informed Forecasting Strategy Enhancement

Feng Li, Taozhu Ruan ยท 2026

We propose a three-stage framework named as Recovery-Informed Strategy Enhancement (RISE) to forecast the recovery of Chinese outbound tourism following the coronavirus disease 2019 pandemic. The framโ€ฆ

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AI & Data Science Preprint PDF DOI

Evaluating the Impact of COVID-19 on Transportation Infrastructure Funding

Lu Gao, Pan Lu, Fengxiang Qiao, Joshua Qiang Li, Yunpeng Zhang, Yihao Ren ยท 2026

The coronavirus disease 2019 (COVID-19) pandemic has caused a reduction in business and routine activity and resulted in less motor fuel consumption. Thus, the gas tax revenue is reduced which is the โ€ฆ

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Engineering Preprint PDF DOI

Navigating heterogeneous protein landscapes through geometry-aware smoothing

Srinivas Anumasa, Barath Chandran, Tingting Chen, Nuwaisir Mohammad Rahman, Yingtao Zhu, Rushi Shah, Hongyu He, Peisong Zhang, Yizhen Liao, Yiming Tang, Yong Shen, Tianfan Fu, Rui Qing, Xiao Li, Sebastian Maurer-Stroh, Xinyi Su, Zhizhuo Zhang, Dianbo Liu ยท 2026

The evolutionary fitness landscape of biological molecules is extremely sparse and heterogeneous, with functional sequences forming isolated dense ``islands'' within a vast combinatorial space of largโ€ฆ

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Biology & Life Sciences Preprint PDF DOI

Comparative efficacy and safety of pharmacological interventions for the treatment of long COVID in adults: a systematic review and network meta-analysis

Hailu Zhou, Fei Jiang, Zhigang Jiang ยท 2026

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, represents a major global pandemic of the 21st century, with long-term effects termed long COVID. This systematic review and network meta-anaโ€ฆ

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Economics & Finance Preprint PDF DOI

Preventive Care Disruptions and Emergency Hospitalizations: Evidence from COVID-19 and SHARE

Moslem Rashidi, Luke B. Connelly, Gianluca Fiorentini ยท 2025

We study whether disruptions to preventive care during the first wave of the coronavirus disease 2019 pandemic affected subsequent acute hospital use. Using the Survey of Health, Ageing and Retirementโ€ฆ

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AI & Data Science Preprint PDF DOI

Murmur2Vec: A Hashing Based Solution For Embedding Generation Of COVID-19 Spike Sequences

Sarwan Ali, Taslim Murad ยท 2025

Early detection and characterization of coronavirus disease (COVID-19), caused by SARS-CoV-2, remain critical for effective clinical response and public-health planning. The global availability of larโ€ฆ

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AI & Data Science Preprint PDF DOI

Debiasing hazard-based, time-varying vaccine effects using vaccine-irrelevant infections: An observational extension of a pivotal Phase 3 COVID-19 vaccine efficacy trial

Ethan Ashby, Dean Follmann, Holly Janes, Peter B. Gilbert, Ting Ye, Lindsey R. Baden, Hana M. El Sahly, Bo Zhang ยท 2025

Understanding how vaccine effectiveness (VE) changes over time can provide evidence-based guidance for public health decision making. While commonly reported by practitioners, time-varying VE estimateโ€ฆ

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Physics Preprint PDF DOI

Ultrasensitive surface plasmon resonance-based biosensor for efficient detection of SARS-CoV-2 Virus in the near-infrared region

R. Runthala, N. Grover, P. Arora ยท 2025

This work presents a high-performance, multilayered surface plasmon resonance (SPR)-based sensor designed to enhance performance parameters in the near-infrared (NIR) region through angular interrogatโ€ฆ

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AI & Data Science Preprint PDF DOI

A Multimodal Framework for Depression Detection during Covid-19 via Harvesting Social Media: A Novel Dataset and Method

Ashutosh Anshul, Gumpili Sai Pranav, Mohammad Zia Ur Rehman, Nagendra Kumar ยท 2025

The recent coronavirus disease (Covid-19) has become a pandemic and has affected the entire globe. During the pandemic, we have observed a spike in cases related to mental health, such as anxiety, strโ€ฆ

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Mathematics Preprint PDF DOI

Applications of standard and Hamiltonian stochastic Lie systems

Javier de Lucas, Marcin Zajac ยท 2025

A stochastic Lie system on a manifold $M$ is a stochastic differential equation whose dynamics is described by a linear combination with functions depending on $\mathbb{R}^\ell$-valued semi-martigalesโ€ฆ

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Biology & Life Sciences Preprint PDF DOI

On the distributions of restriction sites in human and pangolin sarbecoviruses

Zach Hensel ยท 2025

Since early 2020, several theories have suggested that a distribution of restriction endonuclease recognition sites in the SARS-CoV-2 genome indicates a synthetic origin. The most influential of theseโ€ฆ

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Medicine & Health Preprint PDF DOI

Scalable covalently functionalized black phosphorus hybrids for broadspectrum virucidal activity

Na Xing, Jasmin Er, Ricardo M. Vidal, Sandhya Khadka, Robert Schusterbauer, Maik Rosentreter, Ranen Etouki, Rameez Ahmed, Taylor Page, Philip Nickl, Obida Bawadkji, Anja Wiesner, Joerg Radnik, Vasile-Dan Hodoroaba, Kai Ludwig, Jakob Trimpert, Ievgen S. Donskyi ยท 2025

At the onset of viral outbreaks, broad-spectrum antiviral materials are crucial before specific therapeutics become available. We report scalable, biodegradable black phosphorus (BP) hybrids that provโ€ฆ

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Biology & Life Sciences Preprint PDF DOI

Scalable CVD Graphene Field-Effect Transistor Platform for Viral Detection: Application to COVID-19

Leonardo Martini, Ylea Vlamidis, Ileana Armando, Domenica Convertino, Vaidotas Miseikis, Valerio Voliani, Camilla Coletti ยท 2025

The rapid and global spread of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underscored the urgent need for fast, reliable, and adapโ€ฆ

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Computer Science Preprint PDF DOI

A Biosecurity Agent for Lifecycle LLM Biosecurity Alignment

Meiyin Meng, Zaixi Zhang ยท 2025

Large language models (LLMs) are increasingly integrated into biomedical research workflows--from literature triage and hypothesis generation to experimental design--yet this expanded utility also heiโ€ฆ

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Chemistry Preprint PDF DOI

Machine Learning Integrated Near-Infrared Surface-Enhanced Raman Spectroscopy for Accurate Strain-Level Virus Identification

Na Zhang, Ziyang Wang, Xielin Wang, Gabriel A. Vazquez-Lizardi, Paula Pineiro Varela, Dorleta Jimenez de Aberasturi, David E. Sanchez, Nestor Perea-Lopez, Samuel Lin, Ryeanne Ricker, Edgar Dimitrov, Alexander J. Sredenschek, Kalana D. Halanayake, Yin-Ting Yeh, Julian A. Mintz, Jiarong Ye, Sharon Xiaolei Huang, Huaguang Lu, Elodie Ghedin, Danielle Reifsnyder Hickey, Luis M. Liz-Marzan, Shengxi Huang, Mauricio Terrones ยท 2025

Strain-level identification of viruses is critical for effective public health responses to potential outbreaks, yet current diagnostic methods often lack the necessary speed or sensitivity. Surface-eโ€ฆ

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