Research
Research
Research
Research
69+ open-access research outputs.
Sleep is thought to support memory consolidation and the recovery of optimal energetic regime by reorganizing synaptic connectivity, yet how plasticity across hierarchical brain circuits contributes t…
Understanding how the brain represents the multifaceted properties of words in context is essential for explaining the neural architecture of human language. Here, we combine large-scale psycholinguis…
A fine-grained account of functional selectivity in the cortex is essential for understanding how visual information is processed and represented in the brain. Classical studies using designed experim…
Neurons are spatially extended cells; different parts of a neuron have specific voltage dynamics. Important types of neurons even generate different spikes in different parts of the cell. Neurons' inp…
Accurately predicting distributed cortical responses to naturalistic stimuli requires models that integrate visual, auditory and semantic information over time. We present a hierarchical multimodal re…
Biological and artificial learning systems alike confront the plasticity-stability dilemma. In the brain, neuromodulators such as acetylcholine and noradrenaline relieve this tension by tuning neurona…
How do non-neural organisms, such as the slime mould \textit{Physarum polycephalum}, anticipate periodic events in their environment? We present a minimal, biologically inspired reservoir model that d…
The gut-brain axis has emerged as a key player in the regulation of brain function and cognitive health. Gut microbiota dysbiosis has been observed in preclinical models of Alzheimer's disease and pat…
We study the synchronisation of neurons in a realistic model under the Hodgkin-Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons…
To date, most dendritic studies have predominantly focused on the apical zone of pyramidal two-point neurons (TPNs) receiving only feedback (FB) connections from higher perceptual layers and using the…
Mammalian functional architecture flexibly adapts, transitioning from integration where information is distributed across the cortex, to segregation where information is focal in densely connected com…
Neurons integrate synaptic inputs and convert them to action potential output at electrically distant locations. The computational power of a neuron is hence enhanced by subcellular compartmentalizati…
We are concerned about action selection in the basal ganglia (BG). We quantitatively analyze functions of direct pathway (DP) and indirect pathway (IP) for action selection in a spiking neural network…
This article presents a simple model of the cortex-basal ganglia-thalamus loop, which is thought to serve for action selection and executions, and reports the results of its implementation. The model …
For decades the external globus pallidus (GPe) has been viewed as a passive way-station in the indirect pathway of the cortico-basal ganglia-thalamic (CBGT) circuit, sandwiched between striatal inputs…
One of the hallmark features of neocortical anatomy is the presence of extensive top-down projections into primary sensory areas, with many impinging on the distal apical dendrites of pyramidal neuron…
Mounting experimental evidence suggests that brain-state-specific neural mechanisms, supported by connectomic architectures, play a crucial role in integrating past and contextual knowledge with the c…
The basal ganglia (BG) in the brain exhibit diverse functions for motor, cognition, and emotion. Such BG functions could be made via competitive harmony between the two competing pathways, direct path…
The basal ganglia (BG) show a variety of functions for motor and cognition. There are two competitive pathways in the BG; direct pathway (DP) which facilitates movement and indirect pathway (IP) which…
A feature of the brains of intelligent animals is the ability to learn to respond to an ensemble of active neuronal inputs with a behaviorally appropriate ensemble of active neuronal outputs. Previous…
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