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AI & Data Science Preprint PDF DOI

From LLM-Driven Trading Card Generation to Procedural Relatedness: A Pok\'emon Case Study

Johannes Pfau, Panagiotis Vrettis · 2026

Since the dawn of Trading Card Games, the genre has grown into a multi-billion-dollar industry engaging millions of analog and digital players worldwide. Popular TCGs rely on regular updates, balance …

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AI & Data Science Preprint PDF DOI

LA-Pose: Latent Action Pretraining Meets Pose Estimation

Zhengqing Wang, Saurabh Nair, Prajwal Chidananda, Pujith Kachana, Samuel Li, Matthew Brown, Yasutaka Furukawa · 2026

This paper revisits camera pose estimation through the lens of self-supervised pretraining, focusing on inverse-dynamics pretraining as a scalable alternative to the current trend of fully supervised …

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AI & Data Science Preprint PDF DOI

Learning Rate Engineering: From Coarse Single Parameter to Layered Evolution

Ming-Hong Yao, Di Wang, Jian Cui, Jin-Yan Chen, Zi-Hao Cui, Fa Wang, Chen Wei, Qiu-Ye Yu · 2026

Learning rate scheduling has evolved from the single global fixed rate of early SGD to sophisticated layer-wise adaptive strategies. We systematize this evolution into five generations: (Gen1) global …

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Computer Science Preprint PDF DOI

A Discipline-Agnostic AI Literacy Course for Academic Research: Architecture, Pedagogy, and Implementation

Gideon K. Gogovi · 2026

The rapid integration of generative AI into academic workflows demands curricula that equip students not only with tool proficiency but with the critical judgment to use those tools responsibly in sch…

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Mathematics Preprint PDF DOI

Beyond Linear Additive and Hill Functions: A General Logistic Reformulation of Delay-Coupled Gene Regulatory Networks with Equilibrium Analysis, Hopf Bifurcation, and Lipschitz Stability

Ismail Belgacem · 2026

Hill functions, dominant in gene regulatory network modeling, carry fundamental limitations: at non-integer cooperativity exponents, routine when fitting dose-response data, derivatives diverge at the…

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AI & Data Science Preprint PDF DOI

CARhy: Comprehensive Analyses of Circadian Rhythms in Transcriptomic Experiments with Multiple Conditions

Weiyi Huang, Jerome S. Menet, Samiran Sinha · 2026

Circadian rhythms are endogenous oscillations that regulate various physiological processes and their disruption has been linked to many diseases, making it important to determine how gene-expression …

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Sociology & Anthropology Preprint PDF DOI

Two-Dimensional Structural Characterization of Music Genre Communities in Playlist Co-occurrence Networks

Makoto Takeuchi · 2026

Music genre classification shapes how listeners discover music, how platforms design recommendations, and how sociologists study cultural taste. Yet existing genre labels are inconsistent in granulari…

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Biology & Life Sciences Preprint PDF DOI

How is gene-regulatory evolution affected by cell-to-cell variability?

Leonardo Ivan Estrella Dzib, James Holehouse · 2026

The evolutionary origins of structural features in reconstructed gene-regulatory networks (GRNs) remain poorly understood, especially given the random aspects of gene expression. Here, we extend a cla…

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Biology & Life Sciences Preprint PDF DOI

Robust Clustering Analysis of Genes Related to Age-related Macular Degeneration using RNA-Seq

Brayan Gutierrez, Rinki Ratnapriya, Arko Barman · 2026

Identifying genes associated with diseases is crucial to understanding disease mechanisms and developing therapies. However, identification of individual genes associated with a disease often needs to…

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Economics & Finance Preprint PDF DOI

Sources of Inequality at Birth: The Interplay Between Genes and Parental Socioeconomic Status

Pietro Biroli, Nicolau Martin-Bassols, Andries T. Marees, Hans van Kippersluis, Cornelius A. Rietveld, Pia Arce, Kevin Thom, Stephanie von Hinke, Jeremy Vollen, Titus Galama · 2026

The start of a human's life can be characterized by two lotteries: that of your genes (nature) and the family you were born into (nurture). These set in motion a trajectory, from birth onward, in heal…

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AI & Data Science Preprint PDF DOI

From World-Gen to Quest-Line: A Dependency-Driven Prompt Pipeline for Coherent RPG Generation

Dominik Borawski, Marta Szulc, Robert Chudy, Ma{l}gorzata Giedrowicz, Piotr Mironowicz · 2026

Large Language Models (LLMs) have shown strong potential for narrative generation, but their use in complex, multi-layered role-playing game (RPG) worlds is still limited by issues of coherence, contr…

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Mathematics Preprint PDF DOI

A Combinatorial Optimisation Approach to Multi-factorial Gap-filling in Genome-scale Metabolic Models (GEMs)

Philip Kilby, Sevvandi Kandanaarachchi, Matthew J. Morgan, Amy M. Paten, Mariana Velasque, Andrew C. Warden, Juan P. Molina Ortiz · 2026

Genome-Scale Metabolic Models (GEMs) describe the interactions between genes, proteins, and the biochemical reactions that underpin an organism's metabolism aiming to computationally simulate function…

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Biology & Life Sciences Preprint PDF DOI

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov, Jennifer Hadlock, Armita Nourmohammad · 2026

T-cells are central to SARS-CoV-2 clearance and immunological memory, yet their contribution to the persistence of post-acute sequelae of COVID-19 (PASC) remains poorly understood. The immunological f…

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Biology & Life Sciences Preprint PDF DOI

Learning biophysical models of gene regulation with probability flow matching

Suryanarayana Maddu, Victor Chardes, Michael J. Shelley · 2026

Cellular differentiation is governed by gene regulatory networks, the high-dimensional stochastic biochemical systems that determine the transcriptional landscape and mediate cellular responses to sig…

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Biology & Life Sciences Preprint PDF DOI

Quantifying the effect of phenotype on clustering behaviour in melanoma: from monoculture to co-culture

Nathan Schofield, Richard White, Ruth Baker, Helen Byrne · 2026

Melanoma is an aggressive form of skin cancer. Survival rates are excellent if it is detected early but fall markedly if it metastasises. A key step in early tumour progression is the formation of cel…

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AI & Data Science Preprint PDF DOI

PathMoG: A Pathway-Centric Modular Graph Neural Network for Multi-Omics Survival Prediction

Di Wang, Chupei Tang, Junxiao Kong, Jixiu Zhai, Moyu Tang, Tianchi Lu · 2026

Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose P…

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Engineering Preprint PDF DOI

Beam Scheduling for Cross-Layer ISAC: A Deep Reinforcement Learning Approach

Xiyu Wang, Gilberto Berardinelli, Hei Victor Cheng, Petar Popovski, Ramoni Adeogun · 2026

Resource allocation in integrated sensing and communication (ISAC) systems needs to be optimized to balance the requirements of the communication and sensing modules considering complicated cross-laye…

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Biology & Life Sciences Preprint PDF DOI

Differential Analysis of Microbial Interaction Networks

Marianna Milano, Pietro Hiram Guzzi · 2026

Microbiome studies increasingly indicate that disease-associated shifts cannot be understood from compositional changes alone. The functional architecture of microbial communities encoded in patterns …

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AI & Data Science Preprint PDF DOI

Sparse Reduced-rank Regression Methods for Spatially Misaligned Data with Application to Spatial Transcriptomics

Zitian Wu, Susmita Datta, Arkaprava Roy · 2026

Understanding the spatiotemporal dynamics of disease progression in relation to transcriptomic profiles provides key insights into complex conditions such as Alzheimer disease. To enable such investig…

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Biology & Life Sciences Preprint PDF DOI

A multi-stage soft computing framework for complex disease modelling and decision support: A liver cirrhosis case study

Xueyuan Huang, Yuheng Wang, Yuanzhi He, Siqi Gou, Lu Bai, Wenqian Wu, Peifeng Liu, Aijia Wang, Tianhui Fan, Ze Zhou, Jiayu Xu · 2026

Liver cirrhosis is a major global health problem causing millions of deaths annually, and timely detection with aggressive treatment can significantly improve patients' quality of life. Modelling comp…

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