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AI & Data Science Preprint PDF DOI

AutoSurfer -- Teaching Web Agents through Comprehensive Surfing, Learning, and Modeling

Fazle Elahi Faisal, Qianhui Wu, Baolin Peng, Jianfeng Gao · 2026

Recent advances in multimodal large language models (LLMs) have revolutionized web agents that can automate complex tasks on websites. However, their accuracy remains limited by the scarcity of high-q…

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Earth & Environmental Sciences Preprint PDF DOI

Dynamics of East Atlantic seed vortex populations in global km-scale models

Ben Maybee, Francesca Morris, Juliane Schwendike, Ashar Aslam, Calum Scullion, Richard W. Jones, Dasha Shchepanovska, Kevin I Hodges · 2026

Africa is the primary source of cyclonic vortices over the tropical Atlantic. Over both land and sea, these vortices are entwined with deep convective activity, with the majority being African Easterl…

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Mathematics Preprint PDF DOI

Components of strata of k-differentials and their orbit closures

Paul Apisa, Juliet Aygun · 2026

We obtain a complete classification of components of strata of holomorphic and meromorphic k-differentials. We show that, when genus is at least two and outside of explicit exceptions when k < 4, ther…

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Biology & Life Sciences Preprint PDF DOI

Robust Clustering Analysis of Genes Related to Age-related Macular Degeneration using RNA-Seq

Brayan Gutierrez, Rinki Ratnapriya, Arko Barman · 2026

Identifying genes associated with diseases is crucial to understanding disease mechanisms and developing therapies. However, identification of individual genes associated with a disease often needs to…

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Economics & Finance Preprint PDF DOI

Sources of Inequality at Birth: The Interplay Between Genes and Parental Socioeconomic Status

Pietro Biroli, Nicolau Martin-Bassols, Andries T. Marees, Hans van Kippersluis, Cornelius A. Rietveld, Pia Arce, Kevin Thom, Stephanie von Hinke, Jeremy Vollen, Titus Galama · 2026

The start of a human's life can be characterized by two lotteries: that of your genes (nature) and the family you were born into (nurture). These set in motion a trajectory, from birth onward, in heal…

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Mathematics Preprint PDF DOI

A Combinatorial Optimisation Approach to Multi-factorial Gap-filling in Genome-scale Metabolic Models (GEMs)

Philip Kilby, Sevvandi Kandanaarachchi, Matthew J. Morgan, Amy M. Paten, Mariana Velasque, Andrew C. Warden, Juan P. Molina Ortiz · 2026

Genome-Scale Metabolic Models (GEMs) describe the interactions between genes, proteins, and the biochemical reactions that underpin an organism's metabolism aiming to computationally simulate function…

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AI & Data Science Preprint PDF DOI

PathMoG: A Pathway-Centric Modular Graph Neural Network for Multi-Omics Survival Prediction

Di Wang, Chupei Tang, Junxiao Kong, Jixiu Zhai, Moyu Tang, Tianchi Lu · 2026

Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose P…

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AI & Data Science Preprint PDF DOI

Sparse Reduced-rank Regression Methods for Spatially Misaligned Data with Application to Spatial Transcriptomics

Zitian Wu, Susmita Datta, Arkaprava Roy · 2026

Understanding the spatiotemporal dynamics of disease progression in relation to transcriptomic profiles provides key insights into complex conditions such as Alzheimer disease. To enable such investig…

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Biology & Life Sciences Preprint PDF DOI

A multi-stage soft computing framework for complex disease modelling and decision support: A liver cirrhosis case study

Xueyuan Huang, Yuheng Wang, Yuanzhi He, Siqi Gou, Lu Bai, Wenqian Wu, Peifeng Liu, Aijia Wang, Tianhui Fan, Ze Zhou, Jiayu Xu · 2026

Liver cirrhosis is a major global health problem causing millions of deaths annually, and timely detection with aggressive treatment can significantly improve patients' quality of life. Modelling comp…

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Physics Preprint PDF DOI

Machine Learning for Multi-messenger Probes of New Physics and Cosmology: A Review and Perspective

Andrea Addazi, Konstantin Belotsky, Vitaly Beylin, Timur Bikbaev, Deen Chen, Filippo Fabrocini, Stefano Giagu, Krid Jinklub, Artem Kharakhashyan, Maxim Khlopov, Vladimir Korchagin, Maxim Krasnov, Atharv Mahajan, Antonino Marciano, Andrey Mayorov, Antonio Morais, Roman Pasechnik, Jackson Levi Said, Danila Sopin, Viktor Stasenko, Oem Trivedi · 2026

The multi-messenger exploration of dark matter and physics beyond the Standard Model has emerged as a central direction in modern astro-particle physics, particularly following the discovery of gravit…

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AI & Data Science Preprint PDF DOI

StackFeat RL: Reinforcement Learning over Iterative Dual Criterion Feature Selection for Stable Biomarker Discovery

A. Yermekov, D.A. Herrera-Marti · 2026

Feature selection in high-dimensional genomic data ($d \gg n$) demands methods that are simultaneously accurate, sparse, and stable. Existing approaches either require manual threshold specification (…

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AI & Data Science Preprint PDF DOI

Tail-Greedy Unbalanced Haar Wavelet Segmentation for Copy Number Alteration Data

Maharani Ahsani Ummi, Stuart Barber, Henry M. Wood, Arief Gusnanto · 2026

Detecting copy number alterations (CNAs) from next-generation sequencing data remains challenging, particularly for short segments under noisy conditions. Existing segmentation methods often suffer fr…

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AI & Data Science Preprint PDF DOI

CHRep: Cross-modal Histology Representation and Post-hoc Calibration for Spatial Gene Expression Prediction

Changfan Wang, Xinran Wang, Donghai Liu, Fei Su, Lulu Sun, Zhicheng Zhao, Zhu Meng · 2026

Spatial transcriptomics (ST) enables spatially resolved gene profiling but remains expensive and low-throughput, limiting large-cohort studies and routine clinical use. Predicting spatial gene express…

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Physics Preprint PDF DOI

Extreme events in MLC circuit

Tapas Kumar Pa, Dibakar Ghosh · 2026

The Murali-Lakshmanan-Chua (MLC) circuit is a well-recognized prominent nonlinear, nonautonomous, and dissipative electronic circuit having a versatile chaotic nature. Unraveling the dynamical synergy…

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Computer Science Preprint PDF DOI

The eigenvector centrality of hypergraphs

Changjiang Bu, Haotian Zeng, Qingying Zhang · 2026

A hypergraph is called uniform when every hyperedge contains the same number of vertices, otherwise, it is called non-uniform. In the real world, many systems give rise to non-uniform hypergraphs, suc…

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Mathematics Preprint PDF DOI

On Ricci forms of canonical metrics over noncompact complex manifolds

Hanzhang Yin · 2026

In this paper, we study several types of geometric problems related to the Ricci curvature on noncompact complex manifolds, such as the existence of K\"{a}hler-Einstein metrics on complete K\"{a}hler …

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AI & Data Science Preprint PDF DOI

JASPER: Joint Bayesian Analysis of Spatial Expression via Regression

Pritam Dey, Rajarshi Guhaniyogi, Yang Ni, Bani K. Mallick · 2026

Spatially resolved transcriptomics is a fast-developing set of technologies that enables the measurement of localized gene expression across spatial locations in a sample. Detecting spatially varying …

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Biology & Life Sciences Preprint PDF DOI

Noise-Driven Differentiation via Gene Frustration and Epigenetic Fixation

Davey Plugers, Kunihiko Kaneko · 2026

Gene expression in cells is stochastic, yet differentiation is robust. We propose a mechanism in which frustrated genes with weakly stable intermediate expression undergo noise-driven switching betwee…

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AI & Data Science Preprint PDF DOI

SAVE: A Generalizable Framework for Multi-Condition Single-Cell Generation with Gene Block Attention

Jiahao Li, Jiayi Dong, Peng Ye, Xiaochi Zhou, Haohai Lu, Fei Wang · 2026

Modeling single-cell gene expression across diverse biological and technical conditions is crucial for characterizing cellular states and simulating unseen scenarios. Existing methods often treat gene…

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Biology & Life Sciences Preprint PDF DOI

Quantum AI for Cancer Diagnostic Biomarker Discovery

Mandeep Kaur Saggi, Amandeep Singh Bhatia, Humaira Gowher, Sabre Kais · 2026

Quantum machine learning offers a promising new paradigm for computational biology by leveraging quantum mechanical principles to enhance cancer classification, biomarker discovery, and bioinformatics…

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