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🔍 kumarjit pathak 📄 Peer-Reviewed
Showing 2146 results for "kumarjit pathak" · Peer-Reviewed
Computer Science Peer-Reviewed PDF DOI

Complex Network–Based Change Propagation Path Optimization in Mechanical Product Development

Yong Yin, Shuxin Wang, Jian Zhou · 2022

Change propagation is a process in which a change to one part or element of a developed mechanical product tends to induce additional changes to other elements of the product, and the changes can prop…

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Medicine & Health Peer-Reviewed PDF DOI

Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy.

Z Faidon Brotzakis, Thomas Lohr, Michele Vendruscolo · 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a highly infectious disease that is severely affecting our society and welfare systems. In order to develop thera…

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Medicine & Health Peer-Reviewed PDF DOI

Disparity in Gender Representation of Speakers at National Emergency Medical Services Conferences: A Current Assessment and Proposed Path Forward.

Alexandra Davic, Erin Carey, Erin Lambert, Therese Luckingham, Nikki Mongiello, Randi Peralta, Nicolina Puccio, Kimberly Rivera, Kirsten Torre, Lauren M Maloney · 2021

Gender disparities between Emergency Medicine physicians with regards to salary, promotion, and scholarly recognition as national conference speakers have been well-documented. However, little is know…

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Medicine & Health Peer-Reviewed PDF DOI

COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes.

Lucy MacDonald, Stefano Alivernini, Barbara Tolusso, Aziza Elmesmari, Domenico Somma, Simone Perniola, Annamaria Paglionico, Luca Petricca, Silvia L Bosello, Angelo Carfi, Michela Sali, Egidio Stigliano, Antonella Cingolani, Rita Murri, Vincenzo Arena, Massimo Fantoni, Massimo Antonelli, Francesco Landi, Francesco Franceschi, Maurizio Sanguinetti, Iain B McInnes, Charles McSharry, Antonio Gasbarrini, Thomas D Otto, Mariola Kurowska-Stolarska, Elisa Gremese · 2021

We explored the potential link between chronic inflammatory arthritis and COVID-19 pathogenic and resolving macrophage pathways and their role in COVID-19 pathogenesis. We found that bronchoalveolar l…

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Computer Science Peer-Reviewed PDF DOI

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response.

Nicholas A Mathieu, Ermela Paparisto, Stephen D Barr, Donald E Spratt · 2021

Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa tandem ubiquitin-like prote…

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Medicine & Health Peer-Reviewed PDF DOI

Is there any role of intermittent fasting in the prevention and improving clinical outcomes of COVID-19?: intersection between inflammation, mTOR pathway, autophagy and calorie restriction.

Martin Gnoni, Renato Beas, Raul Vasquez-Garagatti · 2021

The coronavirus disease 2019 (COVID-19) pandemic is provoking a global public health crisis. Even though the academic world is intensively pursuing new therapies, there is still no "game changer" in t…

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Medicine & Health Peer-Reviewed PDF DOI

COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis.

Negin Moghimi, Bahram Eslami Farsani, Masoud Ghadipasha, Gholam-Reza Mahmoudiasl, Abbas Piryaei, Abbas Aliaghaei, Shabnam Abdi, Hojjat-Allah Abbaszadeh, Mohammad-Amin Abdollahifar, Mehdi Forozesh · 2021

To evaluate the incidence of apoptosis within the testes of patients who died from severe acute respiratory syndrome coronavirus 2 (COVID-19) complications, testis tissue was collected from autopsies …

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Medicine & Health Peer-Reviewed PDF DOI

The effect of care transition pathway implementation on patients undergoing joint replacement during the COVID-19 pandemic: a quasi-experimental study from a tertiary care hospital orthopedic department in Beijing, China.

Ya-Ping Xu, Pei-Yu Zhao, Yi-Tong Bai, Shuang Li · 2021

The coronavirus disease (COVID-19) pandemic has had a massive impact on individuals globally. The Chinese government has formulated effective response measures, and medical personnel have been activel…

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Medicine & Health Peer-Reviewed PDF DOI

The Ethical Imperative of Equity in Oncology: Lessons Learned From 2020 and a Path Forward.

Jonathan M Marron, Marjory Charlot, Jacquelyne Gaddy, Abby R Rosenberg · 2021

The COVID-19 pandemic and the simultaneous increased focus on structural racism and racial/ethnic disparities across the United States have shed light on glaring inequities in U.S. health care, both i…

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Medicine & Health Peer-Reviewed PDF DOI

Care pathway and prioritization of rapid testing for COVID-19 in UK hospitals: a qualitative evaluation.

Timothy Hicks, Amanda Winter, Kile Green, Patrick Kierkegaard, D Ashley Price, Richard Body, A Joy Allen, Sara Graziadio · 2021

The second wave of the coronavirus pandemic is now established, occurring at a time of winter pressure on acute care in the NHS. This is likely to be more challenging then the first wave for the diagn…

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Medicine & Health Peer-Reviewed PDF DOI

Reply to Mulla and Pathak: Sleep Apnea and Poor COVID-19 Outcomes: Beware of Causal Intermediates and Colliders.

Brian E Cade, Hassan S Dashti, Syed M Hassan, Susan Redline, Elizabeth W Karlson · 2021
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Medicine & Health Peer-Reviewed PDF DOI

Guidelines for Reopening a Nation in a SARS-CoV-2 Pandemic: A Path Forward.

Terrance L Baker, Jack V Greiner · 2021

Background and Objectives : Action, not fear, is the path forward in the coronavirus infectious disease 2019 (COVID-19) pandemic. Since early 2020, the world's nations have faced conundrums over sever…

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Computer Science Peer-Reviewed PDF DOI

Filling in the Gaps in Metformin Biodegradation: a New Enzyme and a Metabolic Pathway for Guanylurea.

Lambros J Tassoulas, Ashley Robinson, Betsy Martinez-Vaz, Kelly G Aukema, Lawrence P Wackett · 2021

The widely prescribed pharmaceutical metformin and its main metabolite, guanylurea, are currently two of the most common contaminants in surface and wastewater. Guanylurea often accumulates and is poo…

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Medicine & Health Peer-Reviewed PDF DOI

SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway.

Da-Yuan Chen, Nazimuddin Khan, Brianna J Close, Raghuveera K Goel, Benjamin Blum, Alexander H Tavares, Devin Kenney, Hasahn L Conway, Jourdan K Ewoldt, Vipul C Chitalia, Nicholas A Crossland, Christopher S Chen, Darrell N Kotton, Susan C Baker, Serge Y Fuchs, John H Connor, Florian Douam, Andrew Emili, Mohsan Saeed · 2021

SARS-CoV-2 can infect multiple organs, including lung, intestine, kidney, heart, liver, and brain. The molecular details of how the virus navigates through diverse cellular environments and establishe…

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Medicine & Health Peer-Reviewed PDF DOI

Obesity and severe coronavirus disease 2019: molecular mechanisms, paths forward, and therapeutic opportunities.

Tiantian Yan, Rong Xiao, Nannan Wang, Ruoyu Shang, Guoan Lin · 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to have higher pathogenicity among patients with obesity. Obesity, termed as body mass index greater than 30 kg/m 2 , has now been …

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Medicine & Health Peer-Reviewed PDF DOI

Targeting the PI3K/AKT pathway: a potential new weapon in the global fight against SARS-CoV-2?

Salvatore Santamaria · 2021

Commentary on 'Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19' by Sun et al.…

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Medicine & Health Peer-Reviewed PDF DOI

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins.

Youssif M Ali, Matteo Ferrari, Nicholas J Lynch, Sadam Yaseen, Thomas Dudler, Sasha Gragerov, Gregory Demopulos, Jonathan L Heeney, Wilhelm J Schwaeble · 2021

Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be c…

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Medicine & Health Peer-Reviewed PDF DOI

Increase in recruitment upon integration of trial into a clinical care pathway: an observational study.

Kay Por Yip, Simon Gompertz, Catherine Snelson, Jeremy Willson, Shyam Madathil, Syed Sa Huq, Farrukh Rauf, Natasha Salmon, Joyce Tengende, Julie Tracey, Brendan Cooper, Kay Filby, Simon Ball, Dhruv Parekh, Davinder P S Dosanjh · 2021

Many respiratory clinical trials fail to reach their recruitment target and this problem exacerbates existing funding issues. Integration of the clinical trial recruitment process into a clinical care…

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Medicine & Health Peer-Reviewed PDF DOI

Targeting the mA RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication.

Hannah M Burgess, Daniel P Depledge, Letitia Thompson, Kalanghad Puthankalam Srinivas, Rebecca C Grande, Elizabeth I Vink, Jonathan S Abebe, Wesley P Blackaby, Alan Hendrick, Mark R Albertella, Tony Kouzarides, Kenneth A Stapleford, Angus C Wilson, Ian Mohr · 2021

N 6 -methyladenosine (m 6 A) is an abundant internal RNA modification, influencing transcript fate and function in uninfected and virus-infected cells. Installation of m 6 A by the nuclear RNA methylt…

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