Research
Research
Research
Research
20+ open-access research outputs.
The problem of maintaining the output of a positive time-invariant single-input single-output system within a predefined corridor of values is treated. For third-order plants possessing a certain stru…
One of the most important surgical factors is Depth of Anesthesia (DOA) control in patients. The main problem is to overcome the uncertainty and nonlinearity of the system, due to different physiologi…
Pramlintide's capability to delay gastric emptying has motivated its use in artificial pancreas systems, accompanying insulin as a control action. Due to the scarcity of pramlintide simulation models …
Cancer remains a leading cause of death worldwide, necessitating personalized treatment approaches to improve outcomes. Theranostics, combining molecular-level imaging with targeted therapy, offers po…
Automated control of personalized multiple anesthetics in clinical Total Intravenous Anesthesia (TIVA) is crucial yet challenging. Current systems, including target-controlled infusion (TCI) and close…
Current closed-loop insulin delivery algorithms need to be informed of carbohydrate intake disturbances. This can be a burden on people using these systems. Pramlintide is a hormone that delays gastri…
We address the problem of parameter identification for the standard pharmacokinetic/pharmacodynamic (PK/PD) model for anesthetic drugs. Our main contribution is the development of a global optimizatio…
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting stents warrants the development of highly resolved in silico models. These computational models assist in gaini…
DCE-MRI provides information about vascular permeability and tissue perfusion through the acquisition of pharmacokinetic parameters. However, traditional methods for estimating these pharmacokinetic p…
Dynamic positron emission tomography imaging (dPET) provides temporally resolved images of a tracer enabling a quantitative measure of physiological processes. Voxel-wise physiologically-based pharmac…
A closer look at nature has recently brought more interest in exploring and utilizing intra-body communication networks composed of cells as intrinsic, perfectly biocompatible infrastructures to deliv…
This paper presents a model-based control architecture. Based on the Medical Cyber-physical Systems (MCPS) concept, we construct a safe and reliable automatic anesthesia control closed-loop system. Th…
This paper deals with the estimation of regions of attraction (RoAs) under parametric uncertainties for a cancer growth model with combined therapies. We propose a framework of probabilistic certifica…
Recently, Molecular Communication (MC) has been recognized as an enabling technology for nanonetworks where MC is envisioned to enable nanorobots to achieve sophisticated and complex tasks in the huma…
This paper proposes an adaptive neuro-fuzzy framework to improve drug infusion rate in closed-loop control of anesthesia. The proposed controller provides a sub-optimal propofol administration rate as…
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays an important role in diagnosis and grading of brain tumor. Although manual DCE biomarker extraction algorithms boost the diagnostic…
This paper proposes a constrained control scheme for the control of the depth of hypnosis during induction phase in clinical anesthesia. In contrast with existing control schemes for propofol delivery…
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a minimally invasive imaging technique which can be used for characterizing tumor biology and tumor response to radiotherapy. Pharmaco…
Twenty-four male subjects were randomized to receive two oral dosage forms of trihexyphenidyl HCl (alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanol HCl). The dosage regimens were (1) a 5-mg immediat…
UNLABELLED: The distribution of benzodiazepine receptors in the human brain has been widely studied with SPECT using (123)I-iomazenil and semiquantitative approaches, but these methods do not allow qu…
Free open-access publishing with Google Scholar indexing.
Submission Guide →