Research
Research
Research
Research
16,943+ open-access research outputs.
We prove that the directed five-dimensional torus $D_5(m) = \operatorname{Cay}((\mathbb{Z}_m)^5, \{e_0, e_1, e_2, e_3, e_4\})$ has a Hamilton decomposition for every odd integer $m \geq 3$. This is th…
Hill functions, dominant in gene regulatory network modeling, carry fundamental limitations: at non-integer cooperativity exponents, routine when fitting dose-response data, derivatives diverge at the…
Circadian rhythms are endogenous oscillations that regulate various physiological processes and their disruption has been linked to many diseases, making it important to determine how gene-expression …
The evolutionary origins of structural features in reconstructed gene-regulatory networks (GRNs) remain poorly understood, especially given the random aspects of gene expression. Here, we extend a cla…
Identifying genes associated with diseases is crucial to understanding disease mechanisms and developing therapies. However, identification of individual genes associated with a disease often needs to…
The start of a human's life can be characterized by two lotteries: that of your genes (nature) and the family you were born into (nurture). These set in motion a trajectory, from birth onward, in heal…
T-cells are central to SARS-CoV-2 clearance and immunological memory, yet their contribution to the persistence of post-acute sequelae of COVID-19 (PASC) remains poorly understood. The immunological f…
Cellular differentiation is governed by gene regulatory networks, the high-dimensional stochastic biochemical systems that determine the transcriptional landscape and mediate cellular responses to sig…
Melanoma is an aggressive form of skin cancer. Survival rates are excellent if it is detected early but fall markedly if it metastasises. A key step in early tumour progression is the formation of cel…
Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose P…
This work provides new lower bounds on the global (nonlinear) stability limit of pressure-driven two-dimensional plane Poiseuille flow, improving on the energy stability limit, $Re_E$, originally comp…
Microbiome studies increasingly indicate that disease-associated shifts cannot be understood from compositional changes alone. The functional architecture of microbial communities encoded in patterns …
Understanding the spatiotemporal dynamics of disease progression in relation to transcriptomic profiles provides key insights into complex conditions such as Alzheimer disease. To enable such investig…
Liver cirrhosis is a major global health problem causing millions of deaths annually, and timely detection with aggressive treatment can significantly improve patients' quality of life. Modelling comp…
Generative AI acts as a disruptive technological shock to evaluative organizations. In academic peer review, it enters both sides of the market: authors use AI to polish submissions, and reviewers use…
Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tis…
Biomolecular systems are often modeled with partially known nonlinear stochastic dynamics, making state and parameter estimation a central challenge. While Kalman filtering techniques are widely used …
Cathaya argyrophylla is an endangered paleoendemic gymnosperm characterized by restricted ecological adaptability and high pathogen susceptibility. To elucidate its genomic architecture and evolutiona…
In high-dimensional genomic data, the curse of dimensionality (d >> n) and limited sampling make feature selection inherently unstable - a critical barrier to biomarker discovery. We introduce StackFe…
Spatial transcriptomics (ST) enables spatially resolved gene profiling but remains expensive and low-throughput, limiting large-cohort studies and routine clinical use. Predicting spatial gene express…
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