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Chemistry Preprint PDF DOI

KinetiDiff: Docking-Guided Diffusion for De Novo ACVR1 Inhibitor Design in Fibrodysplasia Ossificans Progressiva

Aaryan Patel · 2026

We present KinetiDiff, a structure-based framework for de novo kinase inhibitor design that integrates a Geometry-Complete Diffusion Model with real-time AutoDock Vina gradient guidance. By injecting …

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AI & Data Science Preprint PDF DOI

AlphaCNOT: Learning CNOT Minimization with Model-Based Planning

Jacopo Cossio, Daniele Lizzio Bosco, Riccardo Romanello, Giuseppe Serra, Carla Piazza · 2026

Quantum circuit optimization is a central task in Quantum Computing, as current Noisy Intermediate Scale Quantum devices suffer from error propagation that often scales with the number of operations. …

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Physics Preprint PDF DOI

Classification of Pati--Salam Asymmetric $\mathbb{Z}_2 \times \mathbb{Z}_2$ Heterotic String Orbifolds

Luke A. Detraux, Alon E. Faraggi, Benjamin Percival · 2026

We develop a systematic classification of asymmetric $\mathbb{Z}_2$ orbifold actions in Pati--Salam heterotic string vacua constructed in the free fermionic formulation. Starting from symmetric $\math…

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Physics Preprint PDF DOI

Reality-constrained Minimal Yukawa Structure in SO(10) GUT

Shaikh Saad, Vasja Susic · 2026

We investigate the minimal Yukawa sector of grand unified theories based on $\mathrm{SO}(10)$ symmetry, consisting of a Higgs structure with representations $\mathbf{10}_{\mathbb{R}}\oplus \mathbf{120…

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AI & Data Science Preprint PDF DOI

A Multimodal Foundation Model of Spatial Transcriptomics and Histology for Biological Discovery and Clinical Prediction

Jinxi Xiang, Siyu Hou, Yuchen Li, Ryan Quinton, Xiaoming Zhang, Feyisope Eweje, Xiangde Luo, Yijiang Chen, Zhe Li, Colin Bergstrom, Ted Kim, Sierra Willens, Francesca Maria Olguin, Matthew Abikenari, Andrew Heider, Sanjeeth Rajaram, Joel Neal, Maximilian Diehn, Xiang Zhou, Ruijiang Li · 2026

Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks mol…

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Physics Preprint PDF DOI

A Pati-Salam realization of the Nelson-Barr mechanism

Clara Murgui · 2026

We present a UV completion of the Standard Model in which quarks and leptons are unified under color SU(4). A single fermionic representation, the real antisymmetric, provides the building blocks to a…

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Physics Preprint PDF DOI

Circular Future of Yukawa Unification in Supersymmetric Pati-Salam Model: Stop on Neutralino

Ali Cici, Busra Nis, Cem Salih Un · 2026

We explore the low scale implications of SUSY models based on the gauge symmetry SU(4)_CxSU(2)_LxSU(2)_R. We include the non-holomorphic terms arises from the perturbations on D-branes, which also bre…

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Physics Preprint PDF DOI

LHC Run-3, Dark Matter and Supersymmetric Spectra in the Supersymmetric Pati-Salam Model

Ali Muhammad, Imtiaz Khan, Tianjun Li, Shabbar Raza, Mussawir Khan, and Pirzada · 2026

Driven by the growing agreement between the experimentally measured muon anomalous magnetic moment and its SM prediction, we reexamine phenomenological consequences of the MSSM, which is embedded in t…

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AI & Data Science Preprint PDF DOI

Measuring 3D Spatial Geometric Consistency in Dynamic Generated Videos

Weijia Dou, Wenzhao Zheng, Weiliang Chen, Yu Zheng, Jie Zhou, Jiwen Lu · 2026

Recent generative models can produce high-fidelity videos, yet they often exhibit 3D spatial geometric inconsistencies. Existing evaluation methods fail to accurately characterize these inconsistencie…

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Mathematics Preprint PDF DOI

Discrimination of Dynamic Data via Curvature Sets

Nadezhda Belova, Maxwell Goldberg, Facundo Memoli, Sriram Raghunath, Andrew Xie · 2026

Techniques from topological data analysis (TDA) have proven effective in studying time-dependent data arising in dynamic systems, such as animal swarming behavior and spatiotemporal patterns in neuros…

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AI & Data Science Preprint PDF DOI

Training-Free Spatio-temporal Decoupled Reasoning Video Segmentation with Adaptive Object Memory

Zhengtong Zhu, Jiaqing Fan, Zhixuan Liu, Fanzhang Li · 2026

Reasoning Video Object Segmentation (ReasonVOS) is a challenging task that requires stable object segmentation across video sequences using implicit and complex textual inputs. Previous methods fine-t…

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Physics Preprint PDF DOI

Quantum thermodynamics and semidefinite programming: regularization and algorithms

Emanuele Caputo, Augusto Gerolin, Nataliia Monina, Pavlo Pelikh, Lorenzo Portinale · 2026

We investigate variational problems in quantum thermodynamics at positive temperature, in which admissible states are constrained by prescribed outcomes of a finite set of measurements. We solve a pro…

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Mathematics Preprint PDF DOI

Quartic del Pezzo surfaces over $\mathbb{F}_p(t)$ without quadratic points

Giorgio Navone, Katerina Santicola, Harry C. Shaw, Haowen Zhang · 2026

We construct an infinite family of quartic del Pezzo surfaces over $\mathbb{F}_p(t)$ with no quadratic points, for all primes $p\neq 2$. This answers a question of Colliot--Th\'el\`ene, Creutz and Vir…

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AI & Data Science Preprint PDF DOI

VINA: Variational Invertible Neural Architectures

Shubhanshu Shekhar, Mohammad Javad Khojasteh, Ananya Acharya, Tony Tohme, Kamal Youcef-Toumi · 2026

The distinctive architectural features of normalizing flows (NFs), notably bijectivity and tractable Jacobians, make them well-suited for generative modeling. Invertible neural networks (INNs) build o…

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AI & Data Science Preprint PDF DOI

I Dropped a Neural Net

Hyunwoo Park · 2026

A recent Dwarkesh Patel podcast with John Collison and Elon Musk featured an interesting puzzle from Jane Street: they trained a neural net, shuffled all 96 layers, and asked to put them back in order…

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Physics Preprint PDF DOI

The necessary and sufficient condition for perfect teleportation and superdense coding and all the suitable states for teleportation and superdense coding

Dafa Li · 2026

It is known that two local unitaries (LU) equivalent states possess the same amount of entanglement and can be used to perform the same tasks in quantum information theory (QIT). For a protocol for a …

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Mathematics Preprint PDF DOI

A new improved explicit estimate for $\zeta\left( 1/2+it\right)$

Michael Revers · 2026

In this paper, we present an improved explicit subconvexity result for the Riemann zeta function $\zeta\left( s\right)$ along the critical line $s=1/2+it$, given by Hiary, Patel and Yang in 2024. This…

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Physics Preprint PDF DOI

Photoacoustic Tensile Imaging

Daohuai Jiang, Xuanxuan Ye, Hengrong Lan, Xianzeng Zhang, Fei Gao · 2026

Photoacoustic (PA) imaging combines the high optical absorption contrast of optical imaging with the deep tissue penetration of ultrasound detection, offering great potential for functional imaging an…

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Physics Preprint PDF DOI

Symmetry Nonrestoration in the Pati-Salam Model

N. Okada, A. Stern · 2026

We demonstrate that symmetry need not be restored in the Pati-Salam model, so that $SU(2)_L\otimes SU(2)_R\otimes SU(4)_c$ remains broken to the Standard Model group at temperatures above the Pati-Sal…

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Physics Preprint PDF DOI

Universal Seesaw Pati-Salam Model with P for Strong CP

K.S. Babu, Sumit Biswas · 2025

We develop a universal seesaw version of the Pati-Salam model wherein quarks and leptons of each family are unified into common multiplets transforming as $\psi_L(2,1,4))+ \psi_R((1,2,4)$ under the $S…

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