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Showing 16968 results for "animals" · Peer-Reviewed
Computer Science Peer-Reviewed PDF DOI

Least Squares Generative Adversarial Networks-Based Anomaly Detection

Chang-Ki Lee, Yu-Jeong Cheon, Wook-Yeon Hwang · 2022

Multivariate statistical process control (MSPC) is a technique for detecting anomalies by monitoring several quality characteristics simultaneously. For the MSPC problem, the Hotelling’s T2 contro…

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Medicine & Health Peer-Reviewed PDF DOI

Evidence for antibody as a protective correlate for COVID-19 vaccines.

Kristen A Earle, Donna M Ambrosino, Andrew Fiore-Gartland, David Goldblatt, Peter B Gilbert, George R Siber, Peter Dull, Stanley A Plotkin · 2021

A correlate of protection (CoP) is urgently needed to expedite development of additional COVID-19 vaccines to meet unprecedented global demand. To assess whether antibody titers may reasonably predict…

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Medicine & Health Peer-Reviewed PDF DOI

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding.

Jakob Trimpert, Kristina Dietert, Theresa C Firsching, Nadine Ebert, Tran Thi Nhu Thao, Daria Vladimirova, Susanne Kaufer, Fabien Labroussaa, Azza Abdelgawad, Andele Conradie, Thomas Hofler, Julia M Adler, Luca D Bertzbach, Joerg Jores, Achim D Gruber, Volker Thiel, Nikolaus Osterrieder, Dusan Kunec · 2021

Safe and effective vaccines are urgently needed to stop the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live attenuated vaccine candidates…

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Medicine & Health Peer-Reviewed PDF DOI

A review on the pharmacokinetic properties and toxicity considerations for chloroquine and hydroxychloroquine to potentially treat coronavirus patients.

Fatemeh Askarian, Zahra Firoozi, Alireza Ebadollahi-Natanzi, Solmaz Bahrami, Hamid-Reza Rahimi · 2021

The SARS-CoV-2 virus, caused a novel emerged coronavirus disease, is growing rapidly worldwide. Few studies have evaluated the efficacy and safety of Chloroquine (CQ), an old antimalarial drug, and Hy…

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Medicine & Health Peer-Reviewed PDF DOI

SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay.

Younes Laidoudi, Youssouf Sereme, Hacene Medkour, Stephanie Watier-Grillot, Pierre Scandola, Jacques Ginesta, Virginie Andreo, Claire Labarde, Loic Comtet, Philippe Pourquier, Didier Raoult, Jean-Lou Marie, Bernard Davoust · 2021

Dogs are occasionally susceptible to SARS-CoV-2, developing few or no clinical signs. Epidemiological surveillance of SARS-CoV-2 in dogs requires testing to distinguish it from other canine coronaviru…

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Medicine & Health Peer-Reviewed PDF DOI

Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin.

Guilherme Dias de Melo, Francoise Lazarini, Florence Larrous, Lena Feige, Etienne Kornobis, Sylvain Levallois, Agnes Marchio, Lauriane Kergoat, David Hardy, Thomas Cokelaer, Pascal Pineau, Marc Lecuit, Pierre-Marie Lledo, Jean-Pierre Changeux, Herve Bourhy · 2021

The devastating pandemic due to SARS-CoV-2 and the emergence of antigenic variants that jeopardize the efficacy of current vaccines create an urgent need for a comprehensive understanding of the patho…

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Medicine & Health Peer-Reviewed PDF DOI

Possible Targets of Pan-Coronavirus Antiviral Strategies for Emerging or Re-Emerging Coronaviruses.

Xue Li, Liying Zhang, Si Chen, Hongsheng Ouyang, Linzhu Ren · 2021

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which caused Coronaviruses Disease 2019 (COVID-19) and a worldwide pandemic, is the seventh human coronavirus that has been cross-transmit…

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Medicine & Health Peer-Reviewed PDF DOI

Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy.

Kristian Daniel Ralph Roth, Esther Veronika Wenzel, Maximilian Ruschig, Stephan Steinke, Nora Langreder, Philip Alexander Heine, Kai-Thomas Schneider, Rico Ballmann, Viola Fuhner, Philipp Kuhn, Thomas Schirrmann, Andre Frenzel, Stefan Dubel, Maren Schubert, Gustavo Marcal Schmidt Garcia Moreira, Federico Bertoglio, Giulio Russo, Michael Hust · 2021

Antibodies are essential molecules for diagnosis and treatment of diseases caused by pathogens and their toxins. Antibodies were integrated in our medical repertoire against infectious diseases more t…

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Medicine & Health Peer-Reviewed PDF DOI

A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation.

Lin Kang, Guijuan He, Amanda K Sharp, Xiaofeng Wang, Anne M Brown, Pawel Michalak, James Weger-Lucarelli · 2021

The coronavirus disease 2019 (COVID-19) pandemic underscores the need to better understand animal-to-human transmission of coronaviruses and adaptive evolution within new hosts. We scanned more than 1…

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Medicine & Health Peer-Reviewed PDF DOI

Immunogenicity of low dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates.

Neeltje van Doremalen, Robert J Fischer, Jonathan E Schulz, Myndi G Holbrook, Brian J Smith, Jamie Lovaglio, Benjamin Petsch, Vincent J Munster · 2021

Many different vaccine candidates against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of COVID-19, are currently approved and under development. Vaccine platfor…

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Medicine & Health Peer-Reviewed PDF DOI

Sugar Beet Cultivation in India: Prospects for Bio-Ethanol Production and Value-Added Co-Products.

Ashutosh Kumar Mall, Varucha Misra, Santeshwari, A D Pathak, Sangeeta Srivastava · 2021

Sugar beet is an important crop in the advent of COVID 19 as it has a high potential for ethanol production in less growth span. The life cycle of this crop is of five to six months with a root yield …

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Medicine & Health Peer-Reviewed PDF DOI

Post COVID-19: a solution scan of options for preventing future zoonotic epidemics.

Silviu O Petrovan, David C Aldridge, Harriet Bartlett, Andrew J Bladon, Hollie Booth, Steven Broad, Donald M Broom, Neil D Burgess, Sarah Cleaveland, Andrew A Cunningham, Maurizio Ferri, Amy Hinsley, Fangyuan Hua, Alice C Hughes, Kate Jones, Moira Kelly, George Mayes, Milorad Radakovic, Chinedu A Ugwu, Nasir Uddin, Diogo Verissimo, Christian Walzer, Thomas B White, James L Wood, William J Sutherland · 2021

The crisis generated by the emergence and pandemic spread of COVID-19 has thrown into the global spotlight the dangers associated with novel diseases, as well as the key role of animals, especially wi…

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Medicine & Health Peer-Reviewed PDF DOI

Food Enrichment with Extract Suppresses ACE2 mRNA and Protein Expression in Rats-Possible Implications for COVID-19.

Daniela Jezova, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, Harald Murck · 2021

Angiotensin converting enzyme 2 (ACE2) is a key entry point of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus known to induce Coronavirus disease 2019 (COVID-19). We have recently …

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Medicine & Health Peer-Reviewed PDF DOI

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.

Thomas P Peacock, Daniel H Goldhill, Jie Zhou, Laury Baillon, Rebecca Frise, Olivia C Swann, Ruthiran Kugathasan, Rebecca Penn, Jonathan C Brown, Raul Y Sanchez-David, Luca Braga, Maia Kavanagh Williamson, Jack A Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D Davidson, David A Matthews, Wendy S Barclay · 2021

SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2' cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (PRRAR) at the S1/S2 cl…

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Medicine & Health Peer-Reviewed PDF DOI

Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age.

Niamh McGarry, Carol L Murray, Sean Garvey, Abigail Wilkinson, Lucas Tortorelli, Lucy Ryan, Lorna Hayden, Daire Healy, Eadaoin W Griffin, Edel Hennessy, Malathy Arumugam, Donal T Skelly, Kevin J Mitchell, Colm Cunningham · 2021

Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative…

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Medicine & Health Peer-Reviewed PDF DOI

Experimental Models for SARS-CoV-2 Infection.

Taewoo Kim, Jeong Seok Lee, Young Seok Ju · 2021

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a novel virus that causes coronavirus disease 2019 (COVID-19). To understand the identity, functional characteristics and therapeutic ta…

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Medicine & Health Peer-Reviewed PDF DOI

Animal models of SARS-CoV-2 transmission.

Rory D de Vries, Barry Rockx, Bart L Haagmans, Sander Herfst, Marion Pg Koopmans, Rik L de Swart · 2021

SARS-CoV-2 emerged in China as a zoonotic virus in December 2019. The virus proved to be human-to-human transmissible and its global spread resulted in the ongoing COVID-19 pandemic, associated with h…

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Medicine & Health Peer-Reviewed PDF DOI

SARS-CoV-2 Production in a Scalable High Cell Density Bioreactor.

Anna Offersgaard, Carlos Rene Duarte Hernandez, Anne Finne Pihl, Rui Costa, Nandini Prabhakar Venkatesan, Xiangliang Lin, Long Van Pham, Shan Feng, Ulrik Fahnoe, Troels Kasper Hoyer Scheel, Santseharay Ramirez, Udo Reichl, Jens Bukh, Yvonne Genzel, Judith Margarete Gottwein · 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has demonstrated the value of pursuing different vaccine strategies. Vaccines based on whole viruses, a widely used vaccine te…

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Medicine & Health Peer-Reviewed PDF DOI

United States medical preparedness for nuclear and radiological emergencies.

Andrea Lynn DiCarlo, Mary J Homer, C Norman Coleman · 2021

With the end of the Cold War in 1991, U.S. Government (USG) investments in radiation science and medical preparedness were phased out; however, the events of September 11th , which involved a terroris…

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Medicine & Health Peer-Reviewed PDF DOI

ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low- and middle-income countries.

Shivaprakash M Rudramurthy, Martin Hoenigl, Jacques F Meis, Oliver A Cornely, Valliappan Muthu, Jean Pierre Gangneux, John Perfect, Arunaloke Chakrabarti · 2021

Reports are increasing on the emergence of COVID-19-associated mucormycosis (CAM) globally, driven particularly by low- and middle-income countries. The recent unprecedented surge of CAM in India has …

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