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Mathematics Preprint PDF DOI

Beyond Linear Additive and Hill Functions: A General Logistic Reformulation of Delay-Coupled Gene Regulatory Networks with Equilibrium Analysis, Hopf Bifurcation, and Lipschitz Stability

Ismail Belgacem · 2026

Hill functions, dominant in gene regulatory network modeling, carry fundamental limitations: at non-integer cooperativity exponents, routine when fitting dose-response data, derivatives diverge at the…

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Physics Preprint PDF DOI

Transport characteristics of bulk and edge states in an off-diagonal Aubry--Andr\'e--Harper chain

Moumita Patra · 2026

We investigate quantum transport in an off-diagonal Aubry--Andr\'e--Harper chain. The periodic hopping modulation generates effective internal boundaries that strongly influence the transmission chara…

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AI & Data Science Preprint PDF DOI

CARhy: Comprehensive Analyses of Circadian Rhythms in Transcriptomic Experiments with Multiple Conditions

Weiyi Huang, Jerome S. Menet, Samiran Sinha · 2026

Circadian rhythms are endogenous oscillations that regulate various physiological processes and their disruption has been linked to many diseases, making it important to determine how gene-expression …

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Mathematics Preprint PDF DOI

Non-symmetrically $t$-affine functions revisited

Tibor Kiss, Dora Koroknai · 2026

In 2014, Michal Lewicki and Andrzej Olbry\'s proved that if a real valued function $f$ defined on the real line satisfies the conditional functional equation \[ f(tx + (1-t)y) = t f(x) + (1-t) f(y),\q…

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Biology & Life Sciences Preprint PDF DOI

How is gene-regulatory evolution affected by cell-to-cell variability?

Leonardo Ivan Estrella Dzib, James Holehouse · 2026

The evolutionary origins of structural features in reconstructed gene-regulatory networks (GRNs) remain poorly understood, especially given the random aspects of gene expression. Here, we extend a cla…

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Biology & Life Sciences Preprint PDF DOI

Robust Clustering Analysis of Genes Related to Age-related Macular Degeneration using RNA-Seq

Brayan Gutierrez, Rinki Ratnapriya, Arko Barman · 2026

Identifying genes associated with diseases is crucial to understanding disease mechanisms and developing therapies. However, identification of individual genes associated with a disease often needs to…

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Physics Preprint PDF DOI

Characterization of Thermalization Behaviour in a Generalized Aubry-Andr\'e Model

S. Mal, D. K. Nandy, B. K. Sahoo · 2026

Although random matrix theory provides a fundamental framework for characterizing quantum chaos, encompassing both ergodic and localized phases, a comprehensive understanding of the universal features…

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Economics & Finance Preprint PDF DOI

Sources of Inequality at Birth: The Interplay Between Genes and Parental Socioeconomic Status

Pietro Biroli, Nicolau Martin-Bassols, Andries T. Marees, Hans van Kippersluis, Cornelius A. Rietveld, Pia Arce, Kevin Thom, Stephanie von Hinke, Jeremy Vollen, Titus Galama · 2026

The start of a human's life can be characterized by two lotteries: that of your genes (nature) and the family you were born into (nurture). These set in motion a trajectory, from birth onward, in heal…

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Engineering Preprint PDF DOI

Distributed adaptive estimation for stochastic large regression models

Die Gan, Siyu Xie, Zhixin Liu, Xuebo Zhang · 2026

This paper studies the distributed adaptiveestimation problems for stochastic large regression modelswith an infinite number of parameters. By constructing a re-cursive local cost function, we propose…

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Biology & Life Sciences Preprint PDF DOI

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov, Jennifer Hadlock, Armita Nourmohammad · 2026

T-cells are central to SARS-CoV-2 clearance and immunological memory, yet their contribution to the persistence of post-acute sequelae of COVID-19 (PASC) remains poorly understood. The immunological f…

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Biology & Life Sciences Preprint PDF DOI

Learning biophysical models of gene regulation with probability flow matching

Suryanarayana Maddu, Victor Chardes, Michael J. Shelley · 2026

Cellular differentiation is governed by gene regulatory networks, the high-dimensional stochastic biochemical systems that determine the transcriptional landscape and mediate cellular responses to sig…

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Physics Preprint PDF DOI

Gate-dependent offset charge shifts and anharmonicity in gatemon qubits in the weak tunneling regime

Utkan Gungordu, Rusko Ruskov, Silas Hoffman, Kyle Serniak, Andrew J. Kerman, Charles Tahan · 2026

Gatemon qubits are based on a superconductor-quantum dot-superconductor (S-QD-S) junction which enables in situ electrostatic tuning via a gate electrode. For a single-channel QD this structure gives …

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Biology & Life Sciences Preprint PDF DOI

Quantifying the effect of phenotype on clustering behaviour in melanoma: from monoculture to co-culture

Nathan Schofield, Richard White, Ruth Baker, Helen Byrne · 2026

Melanoma is an aggressive form of skin cancer. Survival rates are excellent if it is detected early but fall markedly if it metastasises. A key step in early tumour progression is the formation of cel…

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AI & Data Science Preprint PDF DOI

PathMoG: A Pathway-Centric Modular Graph Neural Network for Multi-Omics Survival Prediction

Di Wang, Chupei Tang, Junxiao Kong, Jixiu Zhai, Moyu Tang, Tianchi Lu · 2026

Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose P…

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Physics Preprint PDF DOI

Improved global stability bounds for two-dimensional plane Poiseuille flow

Vicente Iligaray, Danilo Aballay, Federico Fuentes · 2026

This work provides new lower bounds on the global (nonlinear) stability limit of pressure-driven two-dimensional plane Poiseuille flow, improving on the energy stability limit, $Re_E$, originally comp…

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Mathematics Preprint PDF DOI

Generalized Aubry-Andr\'e formula and continuity of the intersection spectrum of the Almost Mathieu operator

Anton Gorodetski, Victor Kleptsyn · 2026

We consider the spectrum of the Almost Mathieu operator (AMO) and show that the moments of the restriction of the Lebesgue measure to the intersection spectrum $\text{Leb}|_{\Sigma_{\alpha,\lambda}}$ …

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Biology & Life Sciences Preprint PDF DOI

Differential Analysis of Microbial Interaction Networks

Marianna Milano, Pietro Hiram Guzzi · 2026

Microbiome studies increasingly indicate that disease-associated shifts cannot be understood from compositional changes alone. The functional architecture of microbial communities encoded in patterns …

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AI & Data Science Preprint PDF DOI

Sparse Reduced-rank Regression Methods for Spatially Misaligned Data with Application to Spatial Transcriptomics

Zitian Wu, Susmita Datta, Arkaprava Roy · 2026

Understanding the spatiotemporal dynamics of disease progression in relation to transcriptomic profiles provides key insights into complex conditions such as Alzheimer disease. To enable such investig…

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Biology & Life Sciences Preprint PDF DOI

A multi-stage soft computing framework for complex disease modelling and decision support: A liver cirrhosis case study

Xueyuan Huang, Yuheng Wang, Yuanzhi He, Siqi Gou, Lu Bai, Wenqian Wu, Peifeng Liu, Aijia Wang, Tianhui Fan, Ze Zhou, Jiayu Xu · 2026

Liver cirrhosis is a major global health problem causing millions of deaths annually, and timely detection with aggressive treatment can significantly improve patients' quality of life. Modelling comp…

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Economics & Finance Preprint PDF DOI

Buying the Right to Monitor:Editorial Design in AI-Assisted Peer Review

Zaruhi Hakobyan · 2026

Generative AI acts as a disruptive technological shock to evaluative organizations. In academic peer review, it enters both sides of the market: authors use AI to polish submissions, and reviewers use…

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